Ukunyamezela yimpendulo encitshisiweyo kwinto ngenxa yokuvezwa ngokuphindaphindiweyo, okukhokelela ekubeni ufune ngaphezulu kwayo ukufezekisa iziphumo ezifanayo.
I-CBD ayibopheleli ngokuthe ngqo kwi-CB1 kunye ne-CB2 receptors. Kunoko, ichukumisa ngobunono i-ECS ukuba yenze umsebenzi wayo ngokufanelekileyo.
- I-THC ibangela ukunyamezelana ngakumbi ebantwini.
- I-THC ibophelela ngokuthe ngqo kwii-receptors ze-CB1 kwingqondo, ekhokelela kwimiphumo enamandla ye-psychoactive, ixesha elongezelelweyo lokunciphisa uvakalelo kwi-THC.
- I-CBD ixhathisa uphuhliso lokunyamezela.
- Olunye uphononongo lucebisa ukuba i-CBD inokuchasana nezinye iipropathi ze-THCs 'zengqondo kwaye incede ukunciphisa unyamezelo olubangelwa yi-THC.
- Qala ngedosi ephantsi kwaye unyuse ngokuthe ngcembe.
- Jikelezisa phakathi kweemveliso ezahlukeneyo ze-CBD.
- Thatha ikhefu kwi-CBD.
- Dibanisa amanye amayeza endalo kunye nokutshintsha kwendlela yokuphila.
I-CBD titration yindlela yohlengahlengiso lwedosi ngokuthe ngcembe evumela umzimba wakho ukuba uqhelane, kukunceda ufumane idosi yakho efanelekileyo. Ikuvumela ukuba ufumane ibhalansi egqibeleleyo eyenzelwe iimfuno zakho, ngaphandle kokugqithisa inkqubo yakho ye-endocannabinoid (ECS).
Ewe, ukuxhomekeka kwe-THC luhlobo lokuxhomekeka kwe-cannabis. I-THC (i-tetrahydrocannabinol) yeyona nto iphambili yengqondo efumaneka kwi-cannabis. Xa abantu behlakulela ukuxhomekeka okanye ukuba likhoboka le-cannabis, oko kubandakanya ukuxhomekeka kwi-THC. Ukuxhomekeka kwi-cannabis kubandakanya imeko iyonke yokuxhomekeka kwi-cannabis, ebandakanya iimpawu zokulutha ze-THC. Ke, ukuxhomekeka kwe-THC kunokubonwa njengento ethile yokuxhomekeka kwe-cannabis.
CBD, isithandwa sehlabathi lempilo, uye wafumana abalandeli abaninzi kule minyaka imbalwa idlulileyo - kwaye ngesizathu esihle! Ngenkitha yeenzuzo zempilo ezinokubakhona, ayimangalisi into yokuba abantu bethontelana ukuza kuzama. Kodwa phakathi kwemincili, umbuzo ocinezelayo ubuhlala ezingqondweni zabaninzi: ngaba singayakha iCBD unyamezelo? Njengoko singena kule conundrum, siza kuphonononga ubucukubhede bonyamezelo, izinto ezingaqhelekanga zokusebenzisana kwe-CBD nomzimba wethu, kunye nendlela yokuqinisekisa ukuba lo mmangaliso webhotani uyaqhubeka nokusebenza umlingo wayo. Ke, bopha, mfundi othandekayo, kwaye masiqalise uhambo olunomdla lokutyhila iimfihlakalo zonyamezelo lwe-CBD, ngelixa ugcina izinto zilula kwaye ziphefumla njenge-sitcom oyithandayo.
Yintoni uNyamezelo?
Hayi, ukunyamezela - igama elihlala liphoswa ngapha nangapha, kodwa lithetha ukuthini ngokwenene? Kumxholo wezinto, ukunyamezela yindlela umzimba wakho othi, "Owu, ndiyibonile le nto ngaphambili, mandilungise." Ngamanye amazwi, yimpendulo ecuthiweyo kwinto ngenxa yokuvezwa okuphindaphindiweyo, okukhokelela ekubeni ufune ngaphezulu kwayo ukufezekisa iziphumo ezifanayo. Itheko elimdaka kakhulu, akunjalo?
Ngoku, masithethe ngeentlobo. Kukho abalinganiswa ababini abaphambili kweli bali: ukunyamezela okubukhali kunye nokungapheliyo. Unyamezelo olubukhali lundwendwe oluzenzekelayo oluthi luthi gqi ngokungalindelekanga, lusenza baziwe ubukho babo kwiiyure nje ezimbalwa. Unyamezelo olungapheliyo, kwelinye icala, ngumntu ohlala naye othi chu ngokucotha ukuthatha indawo ethe kratya ngokuhamba kwexesha, aphuhle emva kokutyhileka okuphindaphindiweyo kunye nexesha elide kwinto ethile.
Kubalulekile ukuqaphela ukuba ayizizo zonke izinto ezenziwe zilingana xa kuziwa kukunyamezelana. Abanye abantu abadumileyo kumdlalo wokunyamezelana kubandakanya utywala, i-opioids, kunye necaffeine yethu esiyithandayo (sijonge kuwe, kofu abathandanayo!). Ezi zinto zikholisa ukufuna amanani eyonyukayo ukufezekisa i-buzz, isiqabu, okanye ukugxila njengangaphambili, kusishiya sicinga ukuba umhlobo wethu we-CBD unokulandela ngokulandelayo. Hlala ubukele njengoko sityhila inyani emva kokunyamezela i-CBD!
Isebenza njani i-CBD kuMzimba
Faka inkqubo ye endocannabinoid (ECS), iqhawe elingadumanga elinceda ukugcina izinto zihamba kakuhle. Le nkqubo intsonkothileyo ifana nombhexeshi weokhestra, eqinisekisa ukuba zonke iimvumi (okanye, kwimeko yethu, imisebenzi yomzimba) zidlala kunye ngemvisiswano.
Ngokungafaniyo nomzala odumileyo we-CBD, THC, I-CBD ayibopheleli ngokuthe ngqo kwi-CB1 kunye ne-CB2 receptors. Endaweni yoko, ithatha indima efihlakeleyo ngakumbi, ichukumisa ngobunono i-ECS ukuba yenze umsebenzi wayo ngokufanelekileyo. I-CBD yenza njengaloo mhlobo uxhasayo, uphucula umsebenzi we-endocannabinoids kunye nokunceda i-ECS igcine i-homeostasis - loo nto ibhalansi ebaluleke kakhulu egcina imizimba yethu.
Imeko yangoku yoPhando ngoNyamezelo lwe-CBD
Njengoko siqhubeka nomnqweno wethu wokutyhila inyani malunga nokunyamezela i-CBD, makhe sijonge imeko yangoku yophando. Ngoku, ngelixa i-CBD ibeka izinto zayo kwihlabathi lezempilo, izazinzulu bezixakekile emva kwezigcawu, zizama ukufumana umfanekiso ocacileyo wale khompawundi inzima. Ke, bafumene ntoni malunga nokunyamezela kwe-CBD?
Ewe, iindaba ezimnandi zezokuba, ukuza kuthi ga ngoku, uphando lucebisa ukuba i-CBD ayibonakali ngathi ibangela uphuhliso lonyamezelo olubalulekileyo. Izifundo ezibandakanya zombini iimodeli zezilwanyana kunye nabantu zichaze iimpawu ezincinci zokunyamezelana, nasemva kokusetyenziswa ixesha elide. (1) Kubonakala ngathi i-CBD inokuba idlala ngemithetho yayo, yenqaba ukulandela ekhondweni lezihlobo zayo ezidume kakhulu.
Nangona kunjalo, kubalulekile ukukhumbula ukuba ilizwe lophando lwe-CBD lisemncinci kwaye lizaliswe yimibuzo engaphendulwanga. Kukho imida kumaphononongo aqhutywayo ukuza kuthi ga ngoku, kubandakanywa neesampulu ezincinci zobungakanani, iindlela ezahlukeneyo, kunye nokungabikho kophando lwexesha elide. Oku kushiya indawo yokuhlola ngakumbi kunye nokufunyanwa kwindawo yokunyamezela kwe-CBD.
Kukwafanelekile ukuba uqaphele ukuba iimpendulo zomntu ngamnye kwi-CBD zinokwahluka ngenxa yentaphane yezinto, ezinje ngemfuza, imetabolism, kunye nokukhetha kwendlela yokuphila. Kanye njengokuba kungekho bantu babini bafanayo, ngokunjalo namava abo nge-CBD. Oku kugxininisa ngakumbi imfuneko yophando olubanzi nolwahlukeneyo kwixesha elizayo.
Ke, ngelixa imeko yangoku yophando isinika umbono wehlabathi lonyamezelo lwe-CBD, kuninzi ekufuneka sikufundile kwaye sikutyhile. Kodwa ungakhathazeki, siza kukugcina unolwazi njengoko ibali liqhubeka!
I-THC vs Ukunyamezela kwe-CBD
CBD kunye ne-THC inokuba njengabantakwenu kwihlabathi le-cannabinoids, kodwa xa kufikwa kubume babo bemichiza kunye neziphumo, bafana nabazala abakude. Ngelixa babelana ngefomula efanayo yeemolekyuli, ukucwangciswa kweeathom zabo kuyahluka, okukhokelela ekusebenzisaneni okwahlukileyo kunye nezamkeli zomzimba wethu (8). I-THC yikhompawundi edume kakubi ye-psychoactive eyenza "uphezulu" owaziwayo, ngelixa i-CBD ayinxilisi kwaye inconywa ngenxa yeenzuzo zayo zonyango.
I-THC inamandla okwenza unyamezelo. Ibophelela ngokuthe ngqo kwi-CB1 receptors kwingqondo, ekhokelela kwimpembelelo enamandla yengqondo (10). Ngokuhamba kwexesha, imizimba yethu iphendula ngokuthoba ezi zamkeli, ukunciphisa uvakalelo lwabo kwi-THC kwaye ifuna iidosi eziphezulu zesiphumo esifanayo (3). Le nto ibhalwe kakuhle kuzo zombini izilwanyana kunye nezifundo zabantu (2).
Kwelinye icala, utyekelo lwe-CBD lokudlala kakuhle ngenkqubo yethu ye-endocannabinoid inokuchaza ukuchasana kwayo okubonakalayo kuphuhliso lonyamezelo. Njengoko bekutshiwo ngaphambili, i-CBD ayibopheleli ngokuthe ngqo kwi-CB1 okanye i-CB2 receptors; endaweni yoko, ichaphazela iECS ngobuqili ngakumbi (7). Olunye uphononongo lude lucebise ukuba i-CBD inokuchasa ezinye zeempembelelo zengqondo ze-THCs kwaye incede ukunciphisa unyamezelo olubangelwa yi-THC.5).
Isishwankathelo, iyantlukwano kwindlela i-CBD kunye ne-THC edibana ngayo nenkqubo yethu ye-endocannabinoid inokuchaza ukuthambekela kwabo okwahlukileyo xa kuziwa kuphuhliso lwe-THC kunye ne-CBD yokunyamezela. Ngelixa i-THC idume ngonyamezelo lokwakha, i-CBD ibonakala ngathi imatsha ukuya kwisingqi segubu layo, ixhathisa umnqweno wokukhuthaza unyamezelo olubonakalayo kubasebenzisi.
Udidi olukhoyo
I-CBD yoxinzelelo
Ukubandakanya i-CBD kwinkqubo yemihla ngemihla kuye kwaxelwa ngabantu abaninzi ukubonelela ngolawulo loxinzelelo lwendalo. Ngokukhuthaza ukuzola kunye nokulinganisela, i-CBD inokuxhasa ukomelela koxinzelelo kwaye ifake isandla kumgangatho wobomi obuphuculweyo.
FUNDA OKUNGAKUMBI NGE-CBD NOXINEZELEKO →
Indlela yokunciphisa uPhuhliso loNyamezelo lwe-CBD
Ngoku, makhe sihlolisise kwenziwa kanjani ukunciphisa uphuhliso lonyamezelo lwe-CBD, nangona ubungqina ukuza kuthi ga ngoku bubonisa ukuba akunakwenzeka ukuba yenzeke:
- Ukuqala ngedosi ephantsi kwaye ngokunyuka ngokuthe ngcembe: Qala uhambo lwakho lwe-CBD ngedosi encinci kwaye uyandise ngokuthe ngcembe, uvumela umzimba wakho ukuba ulungelelanise kwaye uncede ufumane indawo yakho emnandi. Le ndlela, eyaziwa ngokuba yi "titration," ikuvumela ukuba uchonge elona thamo lifanelekileyo elihlangabezana neemfuno zakho ngaphandle kokuphazamisa inkqubo yakho ye-endocannabinoid. (6)
- Ukujikeleza phakathi kweemveliso ezahlukeneyo ze-CBD: Ukuyixuba ngokusebenzisa iimveliso ezahlukeneyo ze-CBD, ezifana ioyile, capsules, yaye zihloko, inokunceda ukugcina i-ECS yakho kwiinzwane zayo. Olu hlobo lunokunciphisa amathuba okuba umzimba wakho uqhele kakhulu kwimveliso ethile, oko kunokunciphisa uphuhliso lokunyamezela kwe-CBD (11).
- Ukuthatha ikhefu ekusebenziseni i-CBD: Ukuphumeza “iholide ye-CBD” amaxesha ngamaxesha kunokunceda ukugcina ukusebenza kwekhomponi. Ikhefu elifutshane linokunika umzimba wakho ithuba lokusetha kwakhona, okwenza kube lula ukuphuhlisa ukunyamezela (4).
- Ukubandakanya amanye amayeza endalo kunye nokutshintsha kwendlela yokuphila: Gcwalisa ukusetyenziswa kwakho kwe-CBD namanye amayeza endalo kunye nohlengahlengiso lwendlela yokuphila, njenge umzimba, kucamngca, kunye nokulungelelana ukutya. Le ndlela epheleleyo inokukhuthaza impilo-ntle jikelele kwaye inciphise ukuthembela kwakho kwi-CBD kuphela, inciphisa ngakumbi amathuba okwakha ukunyamezelana (9).
Yiya kwi-CBD ngokungafaniyo
Ihlabathi lonyamezelo lwe-CBD lizaliswe nemibuzo engaphendulekiyo. Ngelixa uphando lwangoku lucebisa ukuba i-CBD ayinakwenzeka ukuba ibangele unyamezelo olubalulekileyo xa kuthelekiswa nezinye izinto ezinjenge-THC, kusekho okuninzi ekufuneka kufundwe. Ngokuqonda indlela i-CBD enxibelelana ngayo nenkqubo yethu ye-endocannabinoid kunye nokubeka iliso kumzimba oqhubekayo wophando, sinokwenza izigqibo ezinolwazi malunga nokusetyenziswa kwethu kwe-CBD. Ukunciphisa umngcipheko wokuphuhlisa i-THC okanye ukunyamezela kwe-CBD, cinga ukuqala ngedosi ephantsi, ukujikeleza phakathi kweemveliso ze-CBD ezahlukeneyo, ukuthatha ikhefu ekusebenziseni, kunye nokubandakanya ezinye izilungiso zendalo kunye nokutshintsha kwendlela yokuphila. Ngokusondela kwi-CBD ngokufun' ukwazi kunye nemvakalelo yokuzonwabisa, sinokuqhubeka siphonononga iingenelo ezinokubakho kwaye sityhile iimfihlo ezigcinwe yile khompawundi inomdla.
Izikhokelo ezininzi ze-CBD | Fumana idosi yakho ye-CBD
Ingakanani i-CBD ekufuneka ndiyisebenzise? | Ukufumana ubungakanani obugqibeleleyo bokusebenzela wena ngokusekwe kwinqanaba leentlungu
Imisebenzi ikhankanyiwe
1. Bergamaschii, Mateus M., et al. "Ukhuseleko kunye neziphumo ebezingalindelekanga ze-cannabidiol, indawo yeCannabis sativa." I-PubMed, ngo-1 Septemba 2011, https://pubmed.ncbi.nlm.nih.gov/22129319/. Ifikeleleke nge-29 ka-Epreli 2023.
2. UGonzalez, uSara, kunye nabanye. "Ukunyamezela kwe-Cannabinoid kunye nokuxhomekeka: ukuphononongwa kwezifundo kwizilwanyana zaselabhoratri." I-PubMed, ngo-2005, https://pubmed.ncbi.nlm.nih.gov/15919107/. Ifikeleleke nge-29 ka-Epreli 2023.
3. Hirvonen, J., et al. "Ukubuyisela umva kwaye kukhethwe ngokwengingqi ukulawulwa kwe-brain cannabinoid CB1 receptors kwi-cannabis engapheliyo mihla le." I-PubMed, ngo-2012, https://pubmed.ncbi.nlm.nih.gov/21747398/. Ifikeleleke nge-29 ka-Epreli 2023.
4. U-Huestis, uMarilyn A. "I-Pharmacokinetics ye-Cannabinoid yabantu - i-PMC." I-NCBI, ngo-2007, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689518/. Ifikeleleke nge-29 ka-Epreli 2023.
5. Laprairie, RB, et al. "I-Cannabidiol yimodyuli engalunganga ye-allosteric ye-cannabinoid CB1 receptor." I-NCBI, ngo-2015, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621983/. Ifikeleleke nge-29 ka-Epreli 2023.
6. MacCallum, uCaroline A., kunye noEthan B. Russo. "Iingqwalasela ezisebenzayo kulawulo lwe-cannabis yezonyango kunye nedosi." I-PubMed, nge-4 kaJanuwari 2018, https://pubmed.ncbi.nlm.nih.gov/29307505/. Ifikeleleke nge-29 ka-Epreli 2023.
7. McPartland, John M., et al. "Ngaba i-cannabidiol kunye ne-Δ (9) -tetrahydrocannabivarin imodyuli engalunganga yenkqubo ye-endocannabinoid? Uphononongo olucwangcisiweyo. " I-PubMed, ngo-2015, https://pubmed.ncbi.nlm.nih.gov/25257544/. Ifikeleleke nge-29 ka-Epreli 2023.
8. UMechoulam, uRafael, noLumir Hanus. "Cannabidiol: isishwankathelo semiba ethile yeekhemikhali kunye nekhemesti. Icandelo I: imiba yeekhemikhali. I-PubMed, ngo-2002, https://pubmed.ncbi.nlm.nih.gov/12505688/. Ifikeleleke nge-29 ka-Epreli 2023.
9. Nagarkatti, Prakash, et al. "I-Cannabinoids njengamachiza achasene nokudumba." I-PubMed, ngo-2009, https://pubmed.ncbi.nlm.nih.gov/20191092/. Ifikeleleke nge-29 ka-Epreli 2023.
10, Pertwee, RG. "Iintlobo ngeentlobo ze-CB1 kunye ne-CB2 receptor pharmacology yezityalo ezintathu ze-cannabinoids: i-delta9-tetrahydrocannabinol, i-cannabidiol kunye ne-delta9-tetrahydrocannabivarin." I-PubMed, ngo-2008, https://pubmed.ncbi.nlm.nih.gov/17828291/. Ifikeleleke nge-29 ka-Epreli 2023.
11. URusso, u-Ethan B. "Ukulawula i-THC: i-cannabis synergy enokubakho kunye neziphumo ze-phytocannabinoid-terpenoid entourage." I-PubMed, ngo-2011, https://pubmed.ncbi.nlm.nih.gov/21749363/. Ifikeleleke nge-29 ka-Epreli 2023.
- I-ECS ilawula imisebenzi yomzimba efana nomoya, ukulala, ukuthanda ukutya, kunye nokuphendula ekungakhululeki kunye noxinzelelo.
- I-ECS ine-receptors ye-CB1 kwingqondo kunye nenkqubo ye-nervous central, kunye ne-CB2 receptors kwi-immune system kunye ne-peripheral tissues.
- I-CBD isebenzisana ne-ECS, ikhuthaza ukuphumla kunye nokunciphisa uxinzelelo ngaphandle kwemiphumo ye-psychoactive.
Ingqondo yinxalenye ye-CB1 & CB2 receptors. Ilawula ingcinga, inkumbulo, imvakalelo, ukubamba, izakhono zemoto, umbono, ukuphefumla nokunye.
1 of 19Izintso ziyinxalenye ye-CB1 receptor kwaye zinokuhluza malunga nesiqingatha sekomityi yegazi ngomzuzu ngamnye, ukuba usempilweni.
2 of 19I-Adrenal Gland yinxalenye ye-CB1 receptor & ibekwe phezulu kwizintso nganye.
3 of 19I-Adrenal Gland yinxalenye ye-CB1 receptor. Iqala emlonyeni ize iphele kwi-rectum.
4 of 19Amathambo ayinxalenye ye-CB2 receptor. Amathambo omntu omdala anamathambo angama-206!
5 of 19Inkqubo ye-cariovascular yinxalenye ye-CB2 receptor kwaye iqulethe intliziyo, imithambo yegazi kunye negazi.
6 of 19Iphecana le-GI liyinxalenye ye-CB2 receptor. Iphecana le-GI “liphecana” lokutya kunye nolwelo oluhamba kulo xa luginyiwe kwaye lufunxekile.
7 of 19Amajoni omzimba ayinxalenye ye-CB2 receptor kwaye yinethiwekhi entsonkothileyo yamalungu, iiseli kunye neeproteni ezikhusela umzimba kusulelo.
8 of 19Iiseli zesibindi ziyinxalenye ye-CB1 & CB2 receptors. Baqhekeza amafutha kwaye bavelise amandla.
9 of 19Inkqubo ye-nervous iyinxalenye ye-CB2 receptor. Isebenzisa iindlela zombane kunye neekhemikhali ukunceda onke amalungu omzimba ukuba anxibelelane.
10 of 19I-pancreas yinxalenye ye-CB2 receptor kwaye yenza i-enzymes ukuqhekeza iswekile, amafutha kunye nesitatshi.
11 of 19I-Peripheral Tissues iyingxenye ye-CB2 receptor. Yiyo nje nayiphi na izicubu ezingeyiyo inkxalabo ephambili kumsebenzi wezicubu ezithile zesakhiwo (isikhumba, amathumbu, imiphunga).
12 of 19Udakada yinxalenye ye-CB2 receptor. Ngelixa ungaphila ngaphandle kwayo, i-spleen ilawula inqanaba leeseli ezimhlophe zegazi.
13 of 19Iiseli ezinamafutha ziyingxenye ye-CB1 receptor & zikhethekileyo ukugcina amandla kunye nengqiqo & ukuphendula kwiinguqu kwi-systemic balance balance.
14 of 19Imiphunga yinxalenye ye-CB1 receptor & indima ephambili yinkqubo yotshintshiselwano ngegesi ebizwa ngokuba kukuphefumla (okanye ukuphefumla).
15 of 19Iiseli zemisipha ziyingxenye ye-CB1 receptor & ziiseli ezenza izicubu zomzimba.
16 of 19I-Pituitary Gland yinxalenye ye-CB1 receptor. Ifumaneka kwisiseko sobuchopho umsebenzi wayo ophambili kukugcina i-homeostasis ngaphakathi komzimba.
17 of 19I-Spinal Cord iyingxenye ye-CB1 receptor & ibaleka ukusuka phezulu kwethambo lentamo ephezulu ukuya phezulu kwithambo elisezantsi kumqolo osezantsi.
18 of 19I-Thyroid Gland yinxalenye ye-CB1 receptor. Ibekwe phambi kwentamo yakho, ilawula uninzi lwemisebenzi ebalulekileyo yomzimba wakho ngokuvelisa kunye nokukhupha iihomoni ezithile.
19 of 19Phonononga i-ECS kunye ne-CBD: Cofa nayiphi na indawo kwidayagram ukuze ufumane ulwazi
